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Thank you for submitting your work entitled "Phenotypic plasticity as an adaptation to a functional trade-off" for consideration by eLife . Your article has been reviewed by four peer reviewers (including the Reviewing Editor) and Ian Baldwin as the Senior Editor.

Our decision has been reached after consultation between the reviewers. Based on these discussions and the individual reviews below, we feel that the message is interesting, but it may take you more than 2 months to fix all problems. Our main concerns are in how you performed and interpreted experiments, and in the mathematical model. Thus, we regret to inform you that we reject your submission at its current stage. However, if you can address all our concerns, eLife will be happy to consider a re-submission.

Reviewer #1:

The manuscript by Yi and Dean showed that phenotypic plasticity can evolve to break a functional trade-off between growth and chemotaxis. The manuscript started with a model prediction on how bacteria exposed to fluctuating environment and selection (selecting for growth following by selecting for chemotaxis) should evolve. Indeed, such prediction was shown to hold for early stage of evolution where cells initially evolved to be better at both growth and chemotaxis (my interpretation here differs somewhat from that of authors) and at phase 2 evolved along a Pareto front as cells evolved to be slower grower and faster swimmer. At phase 3 (P3), a single mutation in fliA allowed cells to break this tradeoff. fliA mutant lowered swimming speed during exponential growth when chemotaxis is not selected for, and increased swimming speed and fraction of motile cells at high cell density. The results are interesting. However, major issued will need to be addressed before acceptance.

1) I am not sure that I understand the lack of reproducibility across figures. Mirela blouse Black Uma Outlet Official 100% Original Cheap Online Sale Manchester Great Sale Free Shipping Eastbay 2018 Newest Cheap Online 8aEFtc
shows that ancestor at 0 hr has a swimming speed of 8 μm/s. In Outlet Discount Authentic Discount Footlocker Womens Tiered Sleeve Cold Shoulder Blouse In Color Rich Black Size XS From Sole Society 1State Cheap Sale Official Site Outlet Locations Cheap Online Fake iKJoT4j
, fraction motile in ancestor is close to 0, and the swimming speed is only ~2 8 μm/s ( Figure 3B ). This type of several-fold difference makes me suspicious.

2) Even though mutation in filA does seem to have an effect since fliA mutation is sufficient to increase swimming speed and% motile cells during late stage growth ( Figure 3C and E ), some other mutation(s) in P3 can also yield the same phenotype (compare late stage growth of solid red in cropped jacket Black Chloé Cheap Perfect Cheap And Nice Outlet Low Shipping 8XcsWr
with sold black in Figure 3C , and solid red and solid black in Figure 3E ). My hypothesis is further supposed by the observation that in Figure 2B , the red line seems to show a much more drastic phenotype during early stages than the fliA mutant.

3) The writing is often confusing. For example, Figure 1A makes one believe that they are doing experiments, but Figure 1B and C give the impression of modeling. They do not lay out their model clearly (especially in the fifth paragraph of the main text where chemotaxis enters the game). Note that fitness (growth rate) can be quantified since it is constant during exponential phase. However, for chemotaxis, does population ratio change exponentially over time? In other words, would you get very different results if the duration of chemotaxis assay varies?

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