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For example, the expression:

is lifted to:

The list comprehension notation we saw in Section More Expressions is more general, and applies to anything which has an implementation of both Monad and Alternative :

In general, a comprehension takes the form [ exp | qual1, qual2, …, qualn ] where quali can be one of:

To translate a comprehension [exp | qual1, qual2, …, qualn] , first any qualifier qual which is a guard is translated to guard qual , using the following function:

Then the comprehension is converted to do notation:

Using monad comprehensions, an alternative definition for m_add would be:

While do notation gives an alternative meaning to sequencing, idioms give an alternative meaning to application . The notation and larger example in this section is inspired by Conor McBride and Ross Paterson’s paper “Applicative Programming with Effects” [1] .

First, let us revisit m_add above. All it is really doing is applying an operator to two values extracted from Maybe Int . We could abstract out the application:

Using this, we can write an alternative m_add which uses this alternative notion of function application, with explicit calls to m_app :

Rather than having to insert m_app everywhere there is an application, we can use idiom brackets to do the job for us. To do this, we can give Maybe an implementation of Applicative as follows, where <*> is defined in the same way as m_app above (this is defined in the Idris library):

Using <*> we can use this implementation as follows, where a function application [| f a1 …an |] is translated into pure f <*> a1 <*> … <*> an :

Idiom notation is commonly useful when defining evaluators. McBride and Paterson describe such an evaluator [1] , for a language similar to the following:

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Subsection “Blocking apical constriction does not arrest SG invagination”, last paragraph. The authors state that "the significant 'wiggliness' of the AJs suggests a decrease of cortical tension." I think this is unlikely-in cultured mammalian cells, we and others have found that decreasing cortical tension (e.g., by Rok or myosin inhibition) leads to smoothly rounded cell borders – really wiggly cell borders are likely to reflect actin filaments oriented perpendicular to the membrane.

Subsection “Blocking apical constriction does not arrest SG invagination”. When during the process of convergent elongation of the organ primordium does Fog expression go off?

Subsection “Blocking apical constriction does not arrest SG invagination”. In interpreting their Dia-CA experiments the authors might take a look at Homem and Peifer (Development. 2008 Mar;135( side slit boxy shirt dress Blue Odeeh Sale Official Site Best Seller Buy Cheap 2018 New Natural And Freely Affordable For Sale 2WpnbFL
):1005-18) in which it was observed that Dia-CA increased cortical myosin in the amnioserosa and altered apical constriction.

The only set of data I found was weak was the attempt to rescue Fog by SG specific Fog re-expression. Given the likelihood that levels and timing were not precisely replicated, I think the speculation about non-autonomous functions was not well supported and I would suggest removing this data.

Discussion. The authors mention a number of times the incredibly provocative fact that they may have identified a GPCR related to Mist expressed in the SG. This would be very interesting, but the degree of discussion of this unpublished data in the manuscript seemed unwarranted unless they wanted to add this data.

Subsection “Additional morphogenetic processes take place during SG invagination”, last paragraph. The authors should add the data showing that the tissue level circumferential myosin cable does form in fog mutants – this is a key part of their model. More generally, I think a more careful description of the progression of junctional myosin in wildtype and mutants would be beneficial – it appeared, for example, that it was AP planar polarized before the process began.

The final circuitry diagram in Figure 7L is nice but would be better if supplemented with a diagram showing the cell shape changes themselves and how the authors think apical constriction and tissue level constriction work together.

Reviewer #2:

The manuscript describes the cell biology behind the invagination of salivary gland primordia in the Drosophila embryo. The changes in cell morphology that occur during this process has been published previously, but the present paper incorporates new features (e. g., the pulsatile apical medial myosin networks) that allow comparison to other well characterized morphogenetic movements in Drosophila , especially the ventral furrow and posterior midgut. In many respects (e. g., the involvement of RoK and Folded gastrulation) the SC pathway shows a regulation of apical constriction and myosin activity very similar to these other processes.

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Here is your resulting configuration.

Figure 2: Directory synchronization for the Office 365 dev/test environment

Figure 2 shows the directory synchronizationc for Office 365 dev/test environment, which includes Office 365 and CLIENT1, APP1, and DC1 virtual machines in an Azure virtual network.

An AD FS server provides federated authentication between Office 365 and the accounts in the corp.contoso.com domain hosted on DC1.

To create an Azure virtual machine for ADFS1, fill in the name of your subscription and the resource group and Azure location for your Base Configuration, and then run these commands at the Azure PowerShell command prompt on your local computer.

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to connect to the ADFS1 virtual machine using the ADFS1 local administrator account name and password, and then open a Windows PowerShell command prompt.

To check name resolution and network communication between ADFS1 and DC1, run the ping dc1.corp.contoso.com command and verify that there are four replies.

Next, join the ADFS1 virtual machine to the CORP domain with these commands at the Windows PowerShell prompt on ADFS1.

Figure 3: Adding the AD FS server

Figure 3 shows the addition of the ADFS1 server to the DirSync for Office 365 dev/test environment.

PROXY1 provides proxying of authentication messages between users attempting to authenticate and ADFS1.

To create an Azure virtual machine for PROXY1, fill in the name of your resource group and Azure location, and then run these commands at the Azure PowerShell command prompt on your local computer.

Next, add a rule to the network security group for the CorpNet subnet to allow unsolicited inbound traffic from the Internet to PROXY1's private IP address and TCP port 443. Run these commands at the Azure PowerShell command prompt on your local computer.

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To check name resolution and network communication between PROXY1 and DC1, run the ping dc1.corp.contoso.com command and verify that there are four replies.

Next, join the PROXY1 virtual machine to the CORP domain with these commands at the Windows PowerShell prompt on PROXY1.